Cognitive ageing and Alzheimer’s disease: the cholinergic system redux

Magnesium and Alzheimers Disease: The Cholinergic Hypothesis

The cholinergic deficit in Alzheimer’s disease (AD) remains the cornerstone for the understanding of chemical signal transfer. Hypofunctions of cholinergic systems are significantly involved in the signs and symptoms of senile dementia of the Alzheimer type. Cognitive deficits in AD have been widely associated with dysfunction of the cholinergic system. As a diagnostic marker of AD the activity...

Cognitive reserve in ageing and Alzheimer's disease.

The concept of cognitive reserve provides an explanation for differences between individuals in susceptibility to age-related brain changes or pathology related to Alzheimer's disease, whereby some people can tolerate more of these changes than others and maintain function. Epidemiological studies suggest that lifelong experiences, including educational and occupational attainment, and leisure ...

Cognitive Impairments in Siblings of Alzheimers Disease Patients: Possible Preclinical Signs of the Disease

Specific Agonists and Antagonists of Serotonergic Receptors in the Treatment of Cognitive Symptoms in Alzheimers Disease

In Alzheimer’s disease, decreasing activity of acetylcholine and GABA in the hippocampus and prefrontal cortex are combined with cognitive deficits and with the formation of beta-amyloid. Neurotransmitter alterations in these brain regions are described, while a neurotransmitter imbalance with hypoactivity of muscarinic cholinergic, serotonergic and GABAergic neurons and hyperactivity of noradr...

Ageing, Cognitive Abilities and Retirement Ageing, Cognitive Abilities and Retirement *

We investigate the relationship between ageing, cognitive abilities and retirement using the Survey on Health, Ageing and Retirement in Europe (SHARE), a household panel that offers the possibility of comparing several European countries using nationally representative samples of the population aged 50+. The human capital framework suggests that retirement may cause an increase in cognitive dec...